Discuss How Glycogen is synthesised Angelina Lorenos

DISCUSS HOW GLYCOGEN IS SYNTHESISED GENERAL STRUCTURE INFORMATION animal starch costs polymers of glucose, conjugate by á 1-4 glycosidic bonds. The part points are linked by á 1-6 glycosidic bonds. The branch points legislate at 8, 9 or 10 residue spacings along the linear chain. FORMATION OF UDP GLUCOSE Glucose is transported into cells by a glucose transporter - a membrane bound protein. It is phosphorylated to dress out glucose-6- orthophosphate. This is catalysed by hexokinase. ATP is converted to ADP, which provides the Pi required for the phosphorylation. isomerization of glucose-6-phospate course of actions glucose-1-phosphate. This is catalysed by phosphoglucomtase. The enzyme Uridine diphosphate (UDP) glucose pyrophosphorylase then catalyses the synthesis of UDP glucose from glucose-1-phosphate. UDP glucose is the metabolically active disagreement of glucose, i.e. the form of glucose which is appropriate for animal starch synthesis. This conversi on mustiness occur before glycogen can be synthesised. Glucose Hexokinase Glucose-6-phosphate Phosphoglucomutase Glucose-1-phosphate UDP glucose pyrophosphorylase UTP PPi UDP Glucose pee 2 Pi MAINTENANCE OF FORMATION OF GLYCOGEN Pyrophosphate (PPi) form in this reaction step is hydrolysed to form two phosphate (Pi) species. This enzymatic cleavage is mediated by pyrophosphatase. This step is passing exergonic - about 30kJmol-1 under standard conditions.

This step is relevant to glycogen synthesis since it draws the reaction (UDP-glucose physical composition from glucose-1-phosphate) to the right, maintaining the formation of UDP-glucose and! consequently the formation of the glycogen polymer. FORMATION OF GLYCOGEN FROM UDP GLUCOSE UDP-glucose donates its glucosyl moiety (the excited sugar unit) to the non-reducing leftover of a glycogen branch. The glycogen branch must comprise at least 4 residues of glucose. This extension reaction generates an á 1-4 glycosidic linkage - so called because the link forms between the speed of light 1 of the first appearance glucosyl moiety and carbon 4 of the glucose residue at the consequence of the chain. Glycogen synthase... If you want to sign on a full essay, rear it on our website: OrderCustomPaper.com

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